Evening Star Newspaper, March 14, 1891, Page 12

DR. KOCH’S LYMPH. Experiments Conducted With It in This City by Dr. Geddings. THE TUBERCULOUS BACILLUS. ‘ow It Works in Producing What is Known as Consumption—The Care Taken in Ob- serving All the Conditions of the Various Patients Selected to Test the Remedy. SINGLE TUBERCULAR BACILLUS LAY imprisoned under a glass slide beneath the concentration of « powerful microscope through which a Stan reporter was gazing the other day at the Providence Hospital. At least Dr. Geddings, who owns the bacillus, for exhibition purposes, said it was one, and be had to be believed. It was a small object, more like @ stick than anything else, reddish in color, with a strange resemblance to ladder. Indeed the word small, with its finite refer- ences and relation to things that exist in ordi- nary life, is scarce the word for this purpose. ‘The bacillus was so small that it took = good deal of peering through the lens on the part of the reporter and considerable direction on the part of the doctor for the former to discover it among the crowd of other queer forms and shapes that were keeping it company between the slips of glass. But there was no doubt after all had been explained that this was ‘aine bacillus such as lies at the root of that jread disease, consumption, which rejoices in the more euphonious but Ics: intelligible cog- nomen of phthisis tuberculosis. TT CAME FROM A CONSUMPTIVE PATIENT. This bacillus was but one of a great many that have been fowad and similarly imprisoned under glass by Dr. Geddings as proof positive that the dozen patients whom he is treating at the hospital with the celebrated. Koch's lymph are aillicted with consumption. These are the patients that were gathered here for the pur- pose of making a thorough and careful test of the celebrated remedy that was claimed to be a eure for the terrible scourge that annually car ies off such @ large percentaj ‘ople. When s number” of small vials of the lymph were received here through the courtesy of the minister to Germany President sent a couple of them to Dr. Ham.its1, surgeon gen- of the marine hospital service, for the pur- pose of ofticially determining the exact value of the discovery as regarded consumption pure and simple. Cases of lupus had been so fre- quently cured that there no longer remained any doubt of the efficiency of the lymph in that discase, but there had been grave suspicions thrown upon the efficacy of the material when well-developed cases of consumption were at- tacked. TEN CASES SELECTED. Ten cases of phthisis pulmonaris were se- lected with great care. Six of them came from the Marine Hospital at Baltimore from among the sailor patients there and four others were found in this city. One of them was a woman. All of them were in the first stage of the disease, or the stage of consolidation, the stage in which the lymph is supposed to "have the most favorable eifect. It was thought that if «favorable result could be obtained in this stage there would be demonstration at least that there was some modicum of virtue in the remedy, and there would be given a safeguard that might ultimately be used to. prevent the development of the disease into tle more ad- vanced stages, where it is lest manageable. twas the intention to take only sue as had no signs of too rapid advai in one of them—that of Morgan, whose death was relaicd in these columns some days ago—a mistake was made, caused by the inaccurate Matements of the man himself, who misrepre- tented his true eondition in order to be celected, do coger was he to be treated with the lymph. ALL camercnty EXAMINED. Assoon as the cases had been comfortably installed in the wards of the Providence Hos- pital they were examined thoroughly, weighed and sounded. This last operation is simply a tematic tapping of the chest in order to as- certain the area of the lungs that is dulled by | the disease. A small automatic rubber ham- mer is used and every inch of the chest cover- mg the lungs is carefai disease, is able to do accurately work of detect- ing the sounds of disease, and the greatest pains are taken to insure the most accurate results. As fast as the rubber hammer pointed out a dallness in the chest the area thus detected was marked out on the surface of the skin by iodine, which left a large or small irregular stain of brown to show the inroads of the disease. Thus was the consumption mapped out on the patient at the beginni i a start was made in the ining whether or not the appli- cation of the remedy had effeet. . THE AREA OF DISEASE. These brown spots were odd in their shape, their uniformity and their singular similarity, and yet their odd irregularity. No two of them were exactly alike. No two of them covered exactly the same amount of space. No two of them were of the same shape, yet there was a striking symmetry about thea that showed cer- tain peculiar laws in the development of the disease that have not yet been mastered. Some were exact squares, yét of unequal size, on the two sides of the patient's ch In some cases the spot appeared only on one side, but in the most there were two «pote, to show that thedis- ease had gone into both lungs. and always at the top. ‘The general shape of the lung seemed te be followed, widening, as a rule, downward. In one instance the two marks «eemed to form continuation of each other, while in others they were quite distinct in their relations, As soon as the patients were thus spotted, as it were, they were photographed by Dr. Ged- digs, who is quite an expert knight of the camera. The negatives of these photographs were carefully marked with the name of the patient the date and preserved as a part of the records. The areas of dullness showed in the reversed shades of the negative as a light spot. ‘THE INJECTIONS OF LYMPH. The injections of the lymph were begun on the 2d day of January. They were very small at first, only one milligram, but they pro- duced the most decided reactions. For the earliest injections a regulation Koch's syri was used, this being advised b; sent around each bottle or vial of the remedy. Its main advantage, so it was claimed, was that it could be perfectly sterilized before each use, ec ridded of nosiose end dangerous air germ’ | that might cause the formation of abscesses around the point of injection. This claim was found to be weil founded, but the syringe was soon seen to be cumbersome and uncertain in its delivery of the dilated remedy. It was c posed merely of 2 clase barrel pointed wi we needie. Graduated marks on the glass tube served to regulate the dose, which was forced through the needle by a rougia-looking holiow bail of rubber with small hole in, the Just as long as the finger was held over this hole the flow was even, but when the ball was pressed downward the flexible rabber caused the hole to slip away from the fin and admit the air, and the fluid was caused to drop out instead of going in a eteady stream. For this reason Koch's syringe was abun- doned and an ordinary hypodermic syringe was substituted, which is sterilized after each use by being totally immersed in alcohol for an hour oF so. WHERE THEY WERE WADE. The injections wore made through the skin @f the upper back, between the shoulder seon immediately after the withdrawal of the needle, which intlamed a trifle, but which int within twelve next injection the location of the last one had entirely disap- injections have been made on each fourth day. For example, there is one made today (Saturday), then the patient will have a rest on Sunday and Monday, and on Tuesday next there will be another injection made. ‘The dose is inereased as the condition of the pationt nally red -b reaction oF effcot. iA if e Te, i i Fil # Ti cause of the disease. The bacillus to which Dr. Geddings introduced Tue Stax reporter was captured in this w: Ti a ny . small portion of the sputum, a mere drop, is placed ona glass microscope slide and im- pritoned by means of a minute disc of glass placed over it and fastened down. ‘The slide is then placed under the object glass of a very powerful microscope and carefully examined to detect the presence of those peculiar ladder- shaped forms that are instantly spotted by the scientific exe of the investigator as the tubercle bacilli that are causing such havoc in the ten- der lungs of the patients. ‘THE BACILLUS AND HOW TT WORKS. Science has studied long and diligently over the question of just how the bacillus works in the lung and what are its true effects, since when one can find out how a certain is done there is a great gain made in the stru; to learn how to prevent that damage. It is a case of reasoning from cause to effect ani then toremedy. There is a good deal of popular misapprehension on the part of the unscientific public as to just what the tubercle bacillus is and what it does. As Dr. Geddingg explains, there are folks who have the idea that it is a hairy monster—microscopically a monster, of course—with claws and hooks and teeth ‘and things that tear the flcsh and cause trouble in that way. The popular apprehensfon is that these beasts of prey fly through the air, dan- rous three-fold because unseen, and take the fret opportunity to and into one’s lungs, t > and | and tear and “germify” (this word is a coinage of the misguided public) until consumption comes as mere matter of indammation and irritation. Asa matter of fact, it has been discovered, after long and patient search, that the bacillus is not an animal at all, but is’ merely one of the lowest forms of vegetable life, with a period of existence ranging froma few hours to about three days. ‘Thus it will be seen that the live bacillus, after it gets into the lungs, does not take up @ permanent residence there, but dies after a very short tenancy, leaving asa poison- ous heritage a deposit which has been dignified by the mysterious name of “ptomaine.” pro- nounced just as though the ingenious word- maker had forgotten that there was euch a letter as “p” in the alphabet. The ptomaine is ‘poison, acting tpon the tissue of the lung both in an irritating and a clogging way. It causes inflammation and decay and contagion by proximity, and finally the infection of the en- tire body of the lung, aided by the frosh ar- rivals of bacilli from the outsideland by their self-duplication from within. ‘fue DECAY OF THE LUXG. In short the bacillus forms a dissolving pus within the lung that attacks the tissues of the cells and finally destroys them, and thus gradu- ally deprives the lung of its powers. The resi- due that comes from this decaying process is the sputum that is examined under the glass for the sign boards of the disease. ‘A layman looking through a microscope at a drop of sputum would be led to think that it was just swarming with bacilli. Indeed, he would be inclined to think that it was a wonder that aman could live with such a menagerie within him, but this would not be fair to the bacilli. They do not monopolize so much space in the lungs as all that. It frequent! that there is but one of them on a singl and that one is often half hidden. ‘The spo and objects that the layman takes to be bacilli are but little bits of foreign matter, mucus and possible membrane that come up with the sputum and bang around the bacilli to partially conceal their presence. Here is where the eye our down one’s throat there to nestle and. twist THE EVENING ST. longer in making its appearance, does not reach as high a point, and subsides more tly ghan it did after the first and second 5 ot the There is also a notable diminution critical sweats which formerly marked its defervescence. During the continuance of the fever the severity of the cough and the quantity of the expectoration are markedly i creased, and equally well marked is the di- minution of both cough and expectoration in “the intervals of treatment, which is given every fourth day. : Physical examination shows no change as re- gards the areas of dullness first mapped out,and Yery slight and unimportant changes as to res- piratory sounds. Examination of the sputa, twice repeated, shows practically no change in the number or morphology of the tubercle bacilli. ‘The patients, with the exception of case No. 3, all report themsclves as feeling better, with im- proved appetites, better rest at night, and di- mninished night sweats. A tabular statement of weights showed that 135; of ten pationts had lost esh, and that four gained. e total loss was jograms, and the total gain 2,136. STILL SOME REACTION. In his next report, dated February 18, he said: The dore has not, as yot, in any case been carried beyond the limit of .003 gram which had been reached at the date of the last report. With this dose there is still some “reaction” after each injection, though in two cases in ich this amount was administered on Fob- is an interesting one from the fact that the dis- ease has existed for seventeen years and has been subjected to a varicty of treatment prior to this. Up to this time he has received two injections, and a maximum dose of .002 gram. At present it can only be stated that under both injections he underwent a typical “re- action” of moderate severity, that the ulcer is today partially reabbed over, and that in one angle there has been a growth of new and ap- parently healthy skin. It was in this report that he ennounced the denth of Morgan and gave the facts of the au- topsy, which were reproduced in Tax STAR some days ago. NO DEFINITE CHANGE. On the 25th of February he gave another table of weights, which showed that of ten patients five had lost flesh, two had remained stationary and two had gained. Tho total loss was 7.875 kilos and the total gain nine-tenths of akilo. In regard to the progress of the cases he eaid: As to the cases of pulmonary and laryngeal tuberculosie under treatment, it can only be said that as yot there is no definite change in their condition for better or worse. Under doves of 006 gram of the Ismph, repented on three occasions, two patients showed no febrile reaction and complained of no discomfort. An increase to .007 gram produced in both of them a “reaction,” reaching 33.5 degrees C., and ac- companied by more pain‘and general malaise than has ever before been produced. ‘A microscopical examination of the sputam, on February 23 and 24. showed an absence of tubercle bacilli in cases Nos. 1, 3 and 4. In cases Nos.7, 9 and 11 they were diminished some- what in number. In none of the cases is there any important change in the physical signs. In case No. 11 (tubercle of larynx) the huskiness of voice has of the scientist comes into play. It peers among the scores of bits of things and finally detects the true bacillus, and then it has evi- dence of the presence of disease that is unmis- takable. ‘The progress of a case that is aided by the in- jections of the lymph is marked by a gradual disappearance of bacilli trom the sputum, and finally, asin the case of a cured patient, in their total absence. WHAT THE LYMPH 18. ‘The lymph is a composition of some sort in which the ptomaines of tubercule bacilli are used, and so the disease is fought by its own germs. There has been no satisfactory theory wor ked out as to just how the lymph works in arresting the progress of the disease, but itis certain that in some way, and in varying de- grees, it so acts upon the active ptomaines in its transformed state and reduces their poison- ing power and checks the growth of their fol- lowers in the lang. The curative powers of the remedy are accepted with some doubt by various authorities, but a great many have come to believe that it is of avail in many cases and of no avail in others that are too far advanced or are in just a peculiar stage where the patient is not strong enough to stand a dose sufficiently large to be of benefit. It has been demonstrated beyond a reason. able doubt that the lymph will cure lupu which is a tubercule, cancerous disease of the skin that affects but the surface, but which is Seemingly everlasting and always ‘ancomfort- able. In the case of lupus at the hospital there has been the best of success, ‘The growth aifects the nose and was spreading, so that in time it would have taken hold of the tissues of the entire face and killed the victim. It is not only checked in its growth, but it is healin rapidly and the flesh is returning to its normal condition. Of course when the disease is fully eradicated from the locality there will be an absence of flesh that will be somewhat disfigur- ing, but this can be remedied by the operation of grafting, so that, if care is taken and skill exercised, the patient will ultimately have as good, or almost as good. a nose as ever. ‘The reason why lupus succumbs more read- ily to the influence of the lymph thaa the other disease is that it is more concentrated and ison the surface, so that the seat of trouble is reached without difliculty. ‘The remedy goes at once to the effected parts instead of bavin, to circulate through the system in the bi and thus reach its destination after the fashion of a specific. When the injection is made in this patient's nose the flesh sweils up to « ing extent and becomes very much inflamed, but this effect soon wears off and the member Tetarns to its first condition. The skin is cov- ering over the abcess and the flesh is granulat- ing, as the doctors say, and in all ways there is the best of indications that the gentleman who this unfortunate, though scien- tifically interesting nose, who comes from somewhere in the west, will be discharged be- fore long with a certificate of cure. ‘THE FInsT REPORT. Regular reports have becn received by Sur- geon General Hamilton from Dr. Geddings each week and printed in the abstract that is issued each Saturday from the marine hospital bureau to show the progress of the experi- ments. The first reports dated Januaty 8 and shows, among other facts, ‘the following: Seven cuses were selected for he treatment, six males and one female. Of cases five markedly disappeared, the patient has gained slightly in weight, and cough bas sontewkas d- mii ‘THE CASE OF LUPUS. ‘The case of Iupus brought forth the follow- ing remarks: ‘The case of Inpus, mention of which was made in the last abstract,has been subjected to four injections, the maximum dose attained being .003 gram. It can now be said that the disease is apparently yielding to the remedy. Probably one-fifth of the ulcerated surface has cicatrized,and the remainder presentsa healthy granulating appearance. GOING ALONG SMOOTHLY. The report of March 4 recited that the cases were going along smoothly. Dr. Geddings said: Since my last communication the case of Japs has received three injections. the Inst two ing, respectively, of .00¢ and .005 gram. It was very noticeabla with thess injections that while the general “reaction” was not well marked (33 degrees to 38.4 degrees C.) the local symptoms were very apparent. In both in- tances there was increased redness of the dis- eased urea, the surface was glistening and the surrounding tissues flushed, tense aud with a pulsating feeling. Today at least one-half of the ulcer has skinned over, the remainder is granulating in a perfectly healthy manner. As to other patients, there is no definite change of condition to be reported during the past week. In two cases injected yesterday with .007 gram the “reaction” only réached 37.5 de- grees C., and in both the cough had almost en- tirely abated, night sweats have ceased and the general condition seems improved. In these cases the sputura remains free from bacilli. THE LAST OFFICAL REPORT. Dr. Geddings' last report,dated March 10, isas follows: “In the case of lupus injections of six aud seven milligrams have failed on three oc- casions to produce any general reaction beyond 87.5C. A slight feeling of malaise, moderate frontal headache and a depression of the to 60 per minute have been noted. The manifestations, however, have been ver marked. ‘There have been manifested on cae the Inngs of the tubercular bacilli that are the | creased dosage, the pyrexia (“reaction”) is | lymph, but certainly there has been a marked improvement in some of the cases. This has not been the rule in all. I think it safe to assert that the reason why so disastrous results have ensued, in quite s number of cases has been rather It e diagnostician than because of the remedy used. has been caused by the ivuph injections won cai y the 1 injections when tuned in the Ant stage of tho Rinestes but, at the same time, it cannot be denied that disastrous results have followed its use when administered in the second and third stagea, In regard to the histological changes occurring as the result of the treatment, I hope to furnish you an account at an early date. pointe: soe” CHAPPIES AND THEIR WOES. Lenten Difficulties That Have Caused Dis- tress Among the Dudes. A STAR REPORTER'S TOUR AMONG THE EXQUISITE YOUTHS—VARIOUS TROURLES OF VARIOUS YOUNG ‘MEN—A DOG AS A MATRIMONIAL INDICATOR— SEVERAL TEARYUL TALES. . A Sran reporter started out the other day to make a tour among the chappies of Wash ing- ton. He found thom scattered pretty impar- tially over the whole city, but they were thick- ost in @ certain section in the northwest. Lent being in full blast the chappiés were idle, com- paratively speaking, but none of them showed signs of fasting or humiliation aad their efforts at prayer, it was gathered, were directed toward pious supplications that Lent might speed by rapidly, 80 that the balls and dancing parties might begin again. Nor were any of the chappies clothed in sack cloth and their heads were not besprinkled with sshes, They wore, for the most part, long waterproof coats, for it happened to be raining. and their spirits, strange to say, like their coats, were damp- ened. ‘The first oneencountored was almost in t- ars. He had the glove of his left hand off and was contemplating with looks of unutterable grief his slender little finger. Another chappie was with him, who, taking him affectionately by the elbow, said: “Well, old chappie, what's the matter? Don't look 0 tad. “Matter!” said the other, “there's matter enough and more than enough. Have you no idea of a calamity?’ And with that the poor, grief-stricken fellow inger for his friend's held out the poor little inspection. There was nothing remarkable about it to an ordinary observer. It was a delicate, white little finger, ringed by a band of beaten gold, in which’ there sparkled a diamond and ruby, side by side. ‘The nail was of ordinary length and highly polished, but as his friend looked at it his countenance assumed an expression of real sympathetic grief. In dismay he gasped out: “It's gone!” “Yes,” said the owner of the finger, “it’s gone! ' And it willtake three months for it to Srow out again, and it will be a year before it will look the way it used to—and—and”"— He turned his head aside to hide his emotion. “Come,” said the other, ‘tell me all about it. How did it happen?” THE DISASTER. And then, excitedly, and with many impo- tent expletives, he poured forth his tale of out- Tage and-insult, It appeared from what ho said that the cause of all the trouble was this: Upon the little finger of his left hand there had grown a nail, and he had tended it with especial pride and care, | Ono of the latest fads among the swells is to have the finger nails long, and chappie wished his to be longer than any other cbappie's. The finger nail upon his little finger grew until it was as long as Ah Sin’s, and he rounded its edges and_ polished it ith’ manicures’ powder. As he would 8i and talk it was his custom to raise his hand frequently and look admiringly upon tl itable finger nail, and his pride in it was observed by everybody. Among others who observed it were some mischievous young girls of chappie’s acquaintance, and not Jong ago, as he was paying a call upon them, own to make a very fair display, and as he was, moreover, deeply enamored, he decided to sail in and win. Such « thing as — and losing did not occur to him asa probability. Sohe arrayed himself in all his ee one afternoon and started around to pay ‘is call and to finish the matter BE fo = pie ws th wy the di on e ows, the ‘an mows chapeles and the latter = thes flattered himscif with the idea that no other man ever frequented the charmer’s house often enough to have a wesging acquaintance with her dog. His only rival was a quiet young fellow with gold see tacles and hair parted on the side whom he met there several times, but that such a plain man could beaserious rival fever seemed trithin the range of possibilities. So chappie started out one afternoon to pay his call with perfect confidence in his success. Ax he came near the house he saw that he of the gold-rimmed spectacles was about to go up the steps. The dog was e sidewalk, and as chappie called to him he de- liberately turned away and trotted up. other fellow and thrust his nose in his hand with every manifestation of an intimate and affectionate acquaintance. Yes, it was only too lain. The dog had givon the secret away. The plain, guise young fellow, with his hair parted on'the side, walked into the house as ‘though he had a right to do so and poor chaj pie concluded to defer his call. No wonder is in deep grief, for he heard of the charmer’s engagement to the quiet young man the next day. There are two facts to be deduced from this: The first is that a chappie does sometimes: fall in love, and the second is that it is well to observe how the lady’s dog treats the visitors in order to find out which one has the inside track. The lady may conceal her prefercuces, at the dog will mot conceal his, and their likes and dislikes are gencrally identical. THE MISSING LIXK. ‘There if another dude—if you prefer ‘to use that word—who is somewhat crestfallen, too, and ashe comes from New York he does not receive much sympathy from the local popu- lation. He thinks that the earth is bounded by Harlem river, the Hudson river, East river ghd New York bay. “Metaphorically speaking he looks down on the Washington monument, and to metaphorically sit upon a man of euch exalted conceit is not easy, yet “a bright Wash- ington girl accomplished the feat the other day and that is why the New Yorker is sad. There were a number of local dudes present on the ‘occasion and they went out and iold about it. A certain Washington chappie who is very young and superlative but who is, nevertneloss, very popular, had just left the house were the New Yorker was calling, and the latter thought he was a safe person to make fun of, so he said to his hostess: “Aw! that young man who was here a few moments ago. Is he, aw!—is he of the native breed, or is ho an imported monkey?” “He?” said the la “Oh, he is native, but he is not a monkey at all. Iam told that they Fase, monkeys on Manhattan Island. Is it rue?” “Pawstively, yaws,” said he quickly; “but they do not export them, you know. They only permit their men to travel.” “Well,” she rejoined, “perhaps you are right, but it seems to me they have recently sent among us one that isneither a monkey nor @ man. Thanks, thanks, and pray what is he?” “The missing link,” “she replied, with « smile. a Not Much Ahead. From the Detroit Free Press. “You must lose a good many dollars a year by that man,” was remarked to » Woodward (0; w very poor one. “Then all he eats ix dead lose.” ot altogether. ‘There are offsets.” low?” Vell, all the boys are onto him. In the last yoar we stole three umbrellas and two pairs of gloves from him, and you see he has gone out and left a chicken in that parcel, which we will at once proceed to cabbage. If he thinks he is he carelessly rested his band for a moment over the back of his chair. Quick as a flash one of these wicked girls, paesing back of him with a pair of sharp scissors in her hand, gave a dex- terous snip with them and the beautiful, rounded end of chappie's lovely finger nail was gone. The symmetry of his hands is destroyed. At one cruel stroke all his care and attention have been nullified. WHY ANOTHER ONE WAS TROUBLED. While the writer was ruminating upon the calamity of this poor chappie he met another dodging around the corner with the air of a man who didn’t wish to be seen. He endea ored to glide up the steps of his club in a stealthy manner, but was met face to face by oiler fellow of his own breed. For conve- nience let the steelthy one be called Mr. X and the other Mr. ¥. Here is the conversation that occurred: “Hello! old man, where are you going?” said Y, “Going in to get a cocktail,” replied X. “Well. I say, but look here.’ Why weren't you at tho Blanks’ dinner party last night?” “Had some scruples about going, don’t you know. Fact is, wasn't asked.” “But I thought you said day before yesterday that you were going?” “So I did.” “Hanged it I understand,” said G. “Old boy, you didn’t lie, did you?” “Of course didn’t,” said X, “and I'll tell you all about it, and I'm deuced’eut up about of these occasions, in periods of time ranging from eight to’ twelve hours, decided hyperemia of the discased ‘area and the surrounding — tissuee a eense of throbbing and burning, ir ~eased exudation and the formation of vescicles upon the sur- face of the ulcer and the appearance upon the cheeks of well-marked erythematous eruption persists for twenty-four to thirty hours, and i in some places succeeded by a branny disqu- mation. Granulation and cicatrization are pro- gressing steadily, though more slowly than at first, and the patient shows a gain in weight of 1.477 klos over his previous weight. In cases os. 1 and 3 there has been a marked improve- ment in the past two weeks. In both there is tobe noted a continued absence of turbercle bacilli in the sputum, cessation of night sweats, expectoration very scanty, no cough, ight ‘increase of weight in case No. 1, and m both a diminution in the areas of dullness. mapped out, decrease of the bronchial and in- crease of the vesicular breathing sounds. “In case No. 4 the laryngeal symptoms, after showing decided improvement, have returned with increased severity. In ‘case No.5 the general condition is much worse than at last report. There are now profuse night sweats, severe hectic and increasing debility and pros- are to be classed as tubercle of lung, one as tubercle of larynx and one as tubercle of lung and larynx. are in the first stage of the disease of consolidation), no patient having been submitted to the treatment who presented phfsical signs of softening (forma- tion of cavities). The duration of these cases varies from four months to two years, their ages from eighteen to fifty-one years. In all cases the prosence of the bacillus tnber- culosis was estal by miscroseopical ex- amination of the sputum, the method of stain- ing employed being that of Weiss (see New York Medical Journal, January 17, 1891,) and specimens from each case were preserved for photo-micrographie representatién. In each case the patient was weighed, the areas of dull- hes marked upon the chest aad » photograph of the chest taken. ‘The uniform dose of .001 gm. of the lrmph was first administered on Saturday, January 24, between 10:30 and 11:15 a.m. Pyrexia (reaction) followed in every case, the time of its appearance varying from ten. ainutes to four hours and {isfy minutes, is intensity ranging 38.8 C. 0 Ws degrees C., its duration from six hours to twenty hours. More or less well-defined rigors occurred in every patient, and in eve the subsidence 3f the fever was marked by more or less sweating. But little pain or dis- parently, however, without any severity of On January 27 six of the seven cases above mentioned were again subjected to a treatment of .002 gm. of the lymph. At this time it can tration. Case No. 9 has left the hospital at his own instance in about the same condition as upon admission, certainly with no marked change for better or worse. In case No. 11 the laryngeal symptoms have assumed a great de- gree of severity, the pationt has rapidly lost weight and the treatment has been temporarily suspended.” table of weights shows that since the tatement of weights four of ten, patients have lost weight and six have gaintd. The total loss has been 7.768 kilos and the total 11.827. There have been 127 injections, the maximum dose being seven milligrams. In case number eight there has been a guin of 4.096 kilos, or about nine pounds in a fortnight. CARE TAKEN IN THE EXPERIMENTS. Whatever may be the final results of ‘the ex- periments as regards the cure or the failure cure the patients it is now well established that the marine hospital bureau has canse to con- gratulate itself upon their success when one takes into consideration the care and system and method with which they have been carried on. In fact, they have been higisty -successful up to the present time, and there is no reason to believe that they will not continue to be so in point of scientitic demonstration of the value such care and system that when the final re- sults were promulgated there could be no eriti- cism that the lyiaplt had not been given a fair, unprejudiced tri ‘He said to a Stas reporter ‘esterday: “The experiments wil! be continued for a few weeks yet, as there has been nothin; demonstrated yet to show anything definite. It is too early to whether or not the lymph is what it is cl tobe, but I think the public have received a very erroncous fea of its sof usefuiness, It isiota panacea ¥ any means, but it has application only to limited class ‘of cazes in a certain stage of t it. Well, you know, deah feller, I'm devlich carelees with my invitations aud I suppose it's because I get so many of them. Butthe Dashes give a dinner party every Thursday and they invite you weeks ahead. Nome time ago I got a bid. "I knew it was for some Thursday and I saw it was for some date early in. the spring. and then I never thought anything more about it, and the other night when {heard you say you were going thereto dinner I concluded, without looking any further to sce, that that was my night too. And last night dressed and went up tothe Dlanks at about 7:30 nnd when I got in the hall and was taking off my top coat I saw that there was no card for me in the tray with the names of the men in it, and I was wondering if { was going to take Miss Blank into dinner and was just about to go into the parlor, when I noticed that that old butler of theirs was looking at me very hard, and I had my hand on the portiere and’had just drawn it alittle aside, when the fellow caughs hold of my coat tails and pulled me back. I was alarmed now, so 1 said, *What's the matter, Jeames, in heaven's name?’ ‘Why, sir,’ says he, ‘look ‘ere, sir, thi hain’t your hevening, sir; you've mistook the hevening, sir.’ “Well, I lit out, and when I got home I saw that I bad been invited for the Thursday before.” Here was w pretty pickle indeed, and surely this chappie had a right to be distressed. He had not gone to the dinner party that he had been invited to, and he hadn't sentan excuse, and then he had very nearly gone to the dinner he wasn't invited to. Let us hope he learnt a lesson, and that he will always be careful in the matter of dates hereafter. Of course he can never expect to be the ie of tho Blank’s agein. ‘That he should have forgotten what evening he was asked for was an offense that they won't forgive. ‘The relation of titis misadventure brought out several from his companion, which served to illustrate how careless women sometimes are in writing invi- tations. One, he explained, had invited him to dinner at Tand he had gone only to find that the lady bad neglected to put down the hour |correctly, as it should have been 7:30. Another had asked him, as he thought, todine at the un- earthly hour of 4 in the afternoon, and he had discovered when he arrived on the scene in full evening dress that the trouble was with ip, since he had been merely ‘Another one had asked him to ° WHAT 4 DOG DID. But these were not tho only distressful chap- pies that were encountered on this afternoon, for, by some curious chance, there seemed to be ‘an epidemic of unhappiness am: and the noxt one mot with bed @ woo of countenence that weuld have done credit to an undertaker. It was discov- ered that the cause of his if i Fil getting ahead of us that's ail right. Seen On w Late Tralz. From Munsey's Weekly. L She—"‘George, just turn that seat in front of us over, and we'll have more root Spring Humors, whether itching, burning, ing, 3 pimply, or blotchy, whether of the skin, —o noon aes simple, scrofulous, or hereditary, are now speedily, permanently, and economitally cured by the Cuticura Remedies when the best physicians and all other remedies fail. The almost miraculous cures daily effected by them prove this. No statement is made regarding thei not warranted by the strongest evidence. They are, in truth, the greatest skin cures, blood purifiers, and humor remedies of modern times. They are absolutely pure, and agreeable to the most sensitive, and may be used on the youngest infant and most delicate invalid with gtatifving and unfailing suc cess. Curicura, the great skin cure, instantly allays the most intense itching, burning, and inflammation, permits rest and sleep, Soothes and heals raw and irritated surfaces, clears the skin and scalp of crusts and scales, and restores the hair. Curicura Soap, the only medicated toilet seap, is indispensable in cleansing diseased surfaces; Cuticura Resotvent, the new blood and skin purifier, and greatest of humor remedfes, cleanses the blood of all impurities, and thus re- moves the cause. Hence, the Cuticura Remedies cure every humor of the Spring, from the simplest facial blemishes to the worst case of scrofula, Sale greater than the combined sales of all others. 2-“ How ro Cone Disnasas of Tite Sct axo Boop” mailed free to any adress, 64 pages, 360 Diseases, so Illustrations, roo testimonials. A book of priceless value to every sutiercr. Cunicura Remrpiss are sold everywhere. Price, Cunicuna, sec. Comicura Soar, 2sc.5 Con- ona Resouvent, Sr. Prepared by Porrex Dauc aiso Cumicat, ConronaTiox, Loston. Pimply, Blotchy Skin, "273s iy sh aod hands, pista foger ends with shapeless nails, are prevented and cured by Cuticura Soap, incomparatly the greatest of skin purifiers and beautifiers, while rivaling in delicacy and surpassing in purity the most expensive of toilet and nursery soaps. Tie only medicated toilet socp, and the only sreventive and cure of infizmmation and clogging of the pores, the cause of Pimples, blackheads, rough, red, and oily skin, and simple humors of infants and children. Price, asc. AUCTION SALES. THIS AFTERNOON FUTURE DAYS. W™ towentuat, aver LicuT y T ACCT ‘y virtue of a deed of trust, di recorded in Liber Nee Hod, folio 43 st'seq.. ohe of the lems records for the Distiict “of Comuibia,, and at the request Of the Var ‘secured. thereby, we Will sell at {idn, intron the peeieee on Tilne T 2H DAY OF MAKC! D, 1891, ST FOUROCLOCK fovtowins | al estate, situate in thecity of Wash inctow Coluiubia, and bhown and desinated as all "ee Jot four (4), in square uumbered seventy- readily subdivided, and should co:n- joM of parties in search of valuable -QUARTER CASH, balance in one, Years, 6 per cent per annum, secured deed "of tas? ‘ou ‘property sold, or ll’ can, Rt thio option of the purchaser. A deposit of $200 will be re- Quired at the tine of saie. “If the teruis of sale are not fo. plied ‘uiteen ays from day of sale the trussoes reserve the riclit to resell the 5 Fisk and cost of the deiaulting Gaye" Udversisexsent o: such Teaslo ‘in Souie newspaper Puolisued in Washington, D.C. All couveyancini, ‘of the parchaser. Fevordiny, &¢., atthe cost EDWARD &. Wisco Parcel of land and premises known and. lisungur ‘AN HESTON. Rs" and tof sub lot DORs: RATCLIFFE, DAKE & CU., Auctioneers. aS N THWEST. 0 certain deeds of trast, duly re jst in J.iber 1410, INS et seq and the twountt = Liver 14508, “folio 407 et seq, oF ihe land reage deacrtd innd Yat Wanuincton, Die ithag cert pice or Ag-THE ABOVE SALE 1S POSTPONED ON AC- count of the rain until SATURDAT, FOUL TEEN Tit BAYGE MARCH TAD tao), sane hog wad piace EDWARD 5." WESCUTT, / ESTO: | 2"§ Trustees. ‘Auitioneers. TLE A PARTNERSHIP. On SATURDAY, the FOURTEENTH DAY OF MAKCH, at HALF-PAST FOUK O'CLOCK, I will sell in tront Of the premiscs, lot 12, in square 186,fronting: 22.6 on Q street between Joti and iui by the depth of Soto an alley. This sot has a south trout and is most desirably situated. = lerms: One-fourth cash, balance one,two and Fears at G per cent interest from day of sale,ee roverty sold, oF all cashat purchaser's option. posit required at sale.” Conveyancins, ke. at pi Ser mcest. ied with in ten nice norch #°venieeh, thence east seventy-seven { thence sonth eight () fert six (6) erly in u direct fine to the place ot by a two-story frame dwelling #21 20th st. Paid in ¢ with interest at the | feet nine (i) inches, Ec. Muproved known as promises No. 1) year ater dnte, fe Of six (1) per cent per aman, interest payable semi-annually : note to be secured b deed of trust upon the property roid, option of purchase: or purchasers. Depon.t or haired at tne a male. Conveyancing, recording, Gris of sale to be complied with in ten (10) days, otherwise tasters reserve te rit to ayer ep erty at jue fise and cost of defaulting purtuaser of pur- hasere iter Sve dase’ advert |r cf sth Female in some newspaper publsied in Wastangton, D.C ares WILLIAM Hl. COLLIN! NELSON, OU ON LiOS,. Auctioncers. TPHOMAS DOWLING, Auctioncer. POTOMAC FISHFRIES AT AUCTION. On TUESDAY, MAKCH SEVENT# EN TWELVE U'CLUCK: tu front of fhe Georsttown iat titer Gshersee om the Fotoma”, known as Cloud's Landing. ca ‘Terms cash. THOMAS DOWLIN three on mihI2tdeds RATCLIFFE, DARE & CO., Aucts. ENTIRE CONTENTS _OF HOI . 1122 ONTENTS OF HOUSE NO. 1122 6TH G IN Pat OF PIANO, ; TABLES, EASY ¢ 3 CHAMBER SETS, WARD- NG BED, LOUNGES, MAT. 3 AND BOLSTERS, SIDE- 10) DININ ¥irtue of two (2) writs of fleri facias, tssued out ¢ clerk's office of the Supreme Court of the Dus: trict of Commmbsa, sted. 1 will soil at 5 The horse iuart of & Which the Terms cask, mh10-4 mhlO<kds TRUSTERS: ak ds WOMAN D mba ee, dani ‘EDWARD J. STELLWAGEN, F. B. McGUIRE, Truster, ” , Wah SING CASE. WAS! TENSION TABLES, ASS WAR TON FM PACKER. Adi KATCLUDE, DAL Ss ROOMS Ut Ta, ENNSVEVANIA Nee SDAY " anid by" three bbe wa: rental vase « LHOMAS M. PEELS, Ammen 404 ALE OF IMPROVE SiKEET What TS SOUTH By AL Vom tei cutee on TUE OF Manon. AT WILLIAM A. RICHARDS.) AUSTIN &PRANAKLIN, SATCLIPPE, DARI IWLING, Auctioneer, VALUABLE IMPROVED KIMGMAY FLACK NORTIL ‘at ope eyenettar at leek with witt ES. GALE sist and aljupationt, the Sideat Uhabliabedl ey willy bed 1 Bend of July, 18. sR AND nw treated. Au di Whew BE WISE._DE fared beiore aut ® 30r the Distaact of Coiiut . Ir. A ae works mighty hard—it mugs be locked.” Gentleman who bad been occupying seat— ‘0, by gosh, it ain't locked!” « BICYCLES. Do You Use A Bet: ‘We sell them at the ascending scale of 50c., T5e., $1, $1.50, 82. To suit all sizes and styles of Cyclists. GORMULLY & JEFFREY MFG. 00., Has arrived. It isa beauty and puis all vtiiers to sloop. Call and seit, GEO. 8. ATWATER&C0,, 3 14¢4-28 Penn. ava. POTOMAC RIVER BOATS. NCMPOLK Avo GLb roiny = 7eAanat LAKE * electricity, including staterooms. Bream ‘St whats, terminus Of cable cars. Tucaay, Tvuretay aad’ Sunday" ate, 2. Kound erp, 3.2" 2 Teieblrone Cal LAW 419.3m, 70 NORFOLK ry 5 1 x LELAND GpBERESS MONEOL, days, Wednemiaysand l’ridays, at 5 p.m. uate CONNECTION WITH BUS TOs SYEAatE Pure: gs single sound tps eke 135 Fa w) Faro: #2 angle: rptind Bs ‘anu teows at B. and 0. ticket o a ave. and Hawiey's, 14tn und New York @ further information injure st cont ruars, ‘Lelepuouecall Furs Wise F- tu ‘oa the end ven. Avent, . TL FUUNTTURE, EQUISITES, &c., &e. MAING, MARCH SIXTEENTH, "CLOCK, we will sell at the above named all the Furniture, ‘Carpets, &c.. comained chich the attention of Vuyers is alle, RATCLIFFE, DARit & CO. . -BOURTH MARCH, IROL, AT TEN O'CLOCK A Tight, title, claiin and interest of the det wor jowinz described pre FOKM SPRIN ized ausas City Packing Coupan Satisfy executions No. 1116 Falls Ie Compan: PART PARLOR SUITE, TABLES, CHEK, ASH AND OTH EL Cha aw ET WARE, BEDS? STANDS, CHAS A. SIDEBOARD. TRS.” DESK, , BODY TAPESTRY, 1 CARPETS THKOUGHOUT: THER WITHA FULL AS RATCHIFE, DARE & OO. Auctioneers, SIGNEE'S SALE OF THE ENTIRE 0? G@ STORE No. 2124 FOL SUKEET NOKTHWEST) COM BODA. FOUNTAIN, Tobhccu, Clones: 4 BHELVING, PRESCRIP’ uty rocurged. i sill salt at pate eerie. ae, See : Ce Slee iad eaten smear neces Will then inimediate.y ue sold ia detaiz TDAY MARCH TWENTIETH, at TEN 0 CLOCK, we will sell at dwelling No. 721 Elev- orthwest all the Handsome Purniture, , contained therein. to which we iMvite tention, RATCLIFFE, DAK & CO., ‘Auctioneers. FFE, DARE & CO., Aucts., ‘$20 Penna. ave. n.w. WELL-KEPT HOUSEHOLD FURNITURE AND EF- ¥ CONSISTINGIN FART OF PARUGK ‘THOMAS DOWLING, Auctioneer. CHANCERY SALE OF REAL ESTATE ON FOURTH SIREET EAST NEAM PENNSXLVAMA AVL- By virtue of a decree of the Supreme Court of the Disirict of Columbia, passed” i ity cause No. Baa, wal ‘oller for saie st pubic suction, in frou: ‘ABL RACK, EL MIRKOR, ELEG: CHAMBER” FURNITUKE, "EXTRA RALNUT WARDIOME, | CHELRY AND, OAK CHAMBER *UITES, ODD DRESSING CASES. M. T. TABLES, LOU’ EASY AND ‘AND. houselold furniture hiwe invite weneral atte HATCLIFFE, DAlue & Co. ‘Auctioneers CHANCERY SALE OF VALUABLE IMPROVED NEAL ESTATE ON THE NORTHWEST CORNE NSYLVANIA AVENUE AND FO! SI 87 ORTH WEST ASD ‘And also each eneuing day during the present weak, ‘wo will sell st our Art Rooms, without reserve, © very T HAS NE Dr. BRC if you suffer HES & he oldest cstablistied advert Prompt treatment oO” YOUNG AND MIDDLE ack. eflects o4 indiscretion, ete. et advertise VEE BEEN CONTRADICTED THAT Physictan, Can be consulted daily at 44 Cat., betwoon 435 ame renee vin special or nervous om an: dieram, > B North Fourth st.,"be ow trees akc Yt Gear, i Foreive on “ow to vest cuted abd cng val i the culy’ Puy sician tn the Cnited a all gchers tail, wotwithstanding aD te blo Bane PROF. able venuine a fupeose 1h busimes | removes Zou rf Ly and “nataral-born Clairvoyant, ya an this caty ; born with veil aud. “of secon macht; re jot ‘or stolen | E Tr; caUnes epeedy Arras: Eves, y trvtibles, evil tae cees advice ul Lusi, love, uF aiything Jou ate acu oc mow ty da Sitting, 50. Residen: Hours, 9am. to9p.m Open Suudaya, 479 Hat. aw., between 434 ani Om. AL Lusucs counleutal Nuve ween, BL BAND, READING AND ASTROLOGIST, Tak young Madaioe De Vaiatina, Just arrived trom bu zope. teats ube. three diferent ways; wl remain @ abort